ISSN 1662-4009 (online)

ey0016.15-11 | (1) | ESPEYB16

15.11. A neural circuit for gut-Induced reward

W Han , LA Tellez , MH Perkins , IO Perez , T Qu , J Ferreira , TL Ferreira , D Quinn , ZW Liu , XB Gao , MM Kaelberer , DV Bohorquez , SJ Shammah-Lagnado , G de Lartigue , IE de Araujo

To read the full abstract: Cell. 2018 Oct 18;175(3):665–678.e23.This article reports a critical role for the vagal gut-to-brain axis in motivation and reward amongst the sensory cells of the right vagal nerve. Optogenetic stimulation of the mouse vagal gut-to-brain axis produced reward behaviors. Stimulation of gut-innervating vagal sensory neurons recapped the hallmark effects of s...